Publications

FnCas9 Editor Linked Uniform Detection Assay for COVID 19.

Rhythm Phutela, Sneha Gulati, Manoj Kumar, Souvik Maiti, Debojyoti Chakraborty.

Multiplex Biomarker Techniques, Springer (2022).

Engineered PAM-flexible FnCas9 variants for robust and specific genome editing and diagnostics.

Sundaram Acharya, Asgar Ansari, Seiichi Hirano, Deepanjan Paul, Riya Rauthan, Manoj Kumar, Rhythm Phutela, Sajal Sarkar, Sneha Gulati, Sudipta Mahato, Savitri Maddileti, Vinay Pulimamidi, Indumathi Mariappan, Hiroshi Nishimasu, Osamu Nureki, Souvik Maiti, Debojyoti Chakraborty. Research Square (2021).

FnCas9 based CRISPR diagnostic for rapid and accurate detection of major SARS-CoV2 variants on a paper strip.

Manoj Kumar*, Sneha Gulati*, Asgar H Ansari, Rhythm Phutela, Sundaram Acharya, Mohd Azhar,  Jayaram Murthy, Poorti Kathpalia, Akshay Kanakan, Ranjeet Maurya, Janani Srinivasa Vasudevan, Aparna Murali, Rajesh Pandey, Souvik Maiti, Debojyoti Chakraborty. eLife (2021).

Rapid and accurate nucleobase detection using FnCas9 and its application in COVID-19 diagnosis.

Mohd. Azhar*, Rhythm Phutela*, Manoj Kumar, Asgar Hussain Ansari, Riya Rauthan, Sneha Gulati, Namrata Sharma,  Dipanjali Sinha, Saumya Sharma, Sunaina Singh, Sundaram Acharya, Sajal Sarkar, Deepanjan Paul, Poorti Kathpalia, Meghali Aich, Paras Sehgal, Gyan Ranjan, Rahul C. Bhoyar, Indian CoV2 Genomics & Genetic Epidemiology (IndiCovGEN) Consortium, Khushboo Singhal, Harsha Lad, Pradeep Kumar Patra,  Govind Makharia, Giriraj Ratan Chandak, Bala Pesala, Debojyoti Chakraborty, Souvik Maiti. 

Biosensors and Bioelectronics (2021).

2021

 

CRISPR Cas9 based genome editing in inherited retinal dystrophies. Mayank Bansal, Sundaram Acharya, Saumya Sharma, Rhythm Phutela, Riya Rauthan, Souvik Maiti, Debojyoti Chakraborty. Ophthalmic Genetics (2021)

Low-cost CRISPR diagnostics for resource-limited settings. Sneha Gulati, Souvik Maiti, Debojyoti Chakraborty. Trends in Genetics (2021).

Voices of biotech research. Annabi N, Baker M, Boettiger A, Chakraborty D, Chen Y, Corbett KS, Correia B, Dahlman J, de Oliveira T, Ertuerk A, Yanik MF, Henaff E, Huch M, Iliev ID, Jacobs T, Junca H, Keung A, Kolodkin-Gal I, Krishnaswamy S, Lancaster M, Macosko E, Martínez-Núñez MA, Miura K, Molloy J, Cruz AO, Platt RJ, Posey AD Jr, Shao H, Simunovic M, Slavov N, Takebe T, Vandenberghe LH, Varshney RK, Wang J. Nature Biotechnology (2021)

​Rapid identification and tracking of SARS-CoV-2 variants of concern. Debojyoti Chakraborty, Anurag Agrawal, Souvik Maiti. The Lancet (2021)

2020

Ophthalmic genetics practice and research in India: Vision in 2020. Mayank Bansal, Radhika Tandon, Rohit Saxena, Arundhati Sharma, Sagnik Sen, Alisha Kishore, Pradeep Venkatesh, Souvik Maiti, Debojyoti Chakraborty. American Journal of Medical Genetics. Partc C, seminars in Medical Genetics (2020)

Terminal uridylyl transferase mediated site-directed access to clickable chromatin employing CRISPR-dCas9. Jerrin Thomas George, Mohd. Azhar, Meghali Aich, Dipanjali Sinha, Uddhav B Ambi, Souvik Maiti, Debojyoti Chakraborty, and Seergazhi G Srivatsan. Journal of the American Chemical Society (2020). 
 

2019


Francisella novicida Cas9 interrogates genomic DNA with very high specificity and can be used for mammalian genome editing. Sundaram Acharya*, Arpit Mishra*, Deepanjan Paul*, Asgar Hussain Ansari, Mohd. Azhar, Manoj Kumar, Riya Rauthan, Namrata Sharma, Meghali Aich, Dipanjali Sinha, Saumya Sharma, Shivani Jain, Arjun Ray, Suman Jain, Sivaprakash Ramalingam, Souvik Maiti, and Debojyoti Chakraborty. Proceedings of the National Academy of Sciences (2019)

 

2018


Novel internal regulators and candidate miRNAs within miR-379/miR-656 miRNA cluster can alter cellular phenotype of human glioblastoma.

Subhashree Nayak, Meghali Aich, Anupam Kumar, Suman Sengupta, Prajakta Bajad, Parashar Dhapola, Deepanjan Paul, Kiran Narta, Suvendu Purkrait, Bharati Mehani, Ashish Suri, Debojyoti Chakraborty, Arijit Mukhopadhyay, Chitra Sarkar. Scientific Reports (2018)

 
A G-quadruplex motif at the 3’ end of sgRNAs improves CRISPR-Cas9  based genome editing efficiency. Smita Nahar, Paras Sehgal, Mohd. Azhar, Manish Rai, Amrita Singh, Sridhar Sivasubbu, Debojyoti Chakraborty# and Souvik Maiti#. Chemical Communications. (2018)

2017


LncRNA Panct1 maintains mouse embryonic stem cell identity by recruiting TOBF1 to Oct-Sox sequences in early G1. Debojyoti Chakraborty, Maciej Paszkowski-Rogacz, Nicolas Berger, Li Ding, Jovan Mircetic et al. Cell Reports (2017)

CRISPR-Cas9: a new tool for gene therapy. Saumya Sharma, Souvik Maiti, Debojyoti Chakraborty. eLS (2017)

2016


CRISPR/Cas9: a historical and chemical biology perspective of targeted genome engineering. Amrita Singh, Debojyoti Chakraborty#, and Souvik Maiti#. Chemical Society Reviews (2016)

Inactivation of cancer mutations utilizing CRISPR/Cas9. Christina Gebler, Tim Lohoff, Maciej Paszkowski-Rogacz, Jovan Mircetic, Debojyoti Chakraborty et al. Journal of the National Cancer Institute (2016)


Directed evolution of Brec1: A broad-range recombinase that inactivates HIV-1 in patient-specific humanized mice. Janet Karpinski, Ilona Hauber, Jan Chemnitz, Carola Schäfer, Maciej Paszkowski-Rogacz, Debojyoti Chakraborty et al. Nature Biotechnology (2016)

2015


Targeting Human Long-Noncoding Transcripts by Endoribonuclease-prepared siRNAs. Mirko Theis, Maciej Paszkowski-Rogacz, Ina Weisswange, Debojyoti Chakraborty, Frank Buchholz. Journal of Biomolecular Screening (2015)

Systems Analyses Reveal Shared and Diverse Attributes of Oct4 Regulation in Pluripotent Cells. Li Ding, Maciej Paszkowski-Rogacz, Maria Winzi, Debojyoti Chakraborty, Mirko Theis et al. Cell Systems (2015)

Before 2015


Universal Tre (uTre) recombinase specifically targets the majority of HIV-1 isolates. Janet Karpinski, Jan Chemnitz, Ilona Hauber Josephine Abi-Ghanem, Maciej Paszkowski-Rogacz, Vineeth Surendranath, Debojyoti Chakraborty et al. Journal of the International AIDS Society (2014)


Combined RNAi and localization for functionally dissecting long noncoding RNAs. Debojyoti Chakraborty, Dennis Kappei, Mirko Theis, Anja Nitzsche, Li Ding, Maciej Paszkowski-Rogacz et al. Nature Methods (2012)